LL-37
Antimicrobial peptide with immune-modulating and wound healing properties
Clinical Research Score: 3/5 — Supported by substantial preclinical antimicrobial and immune research, with human clinical evidence still emerging.
Categories: Immune Support, Recovery & Repair
What is LL-37?
LL-37 is your body's own natural antibiotic — and supplementing it is like calling in reinforcements. It's the only cathelicidin peptide humans produce, and it's on the front lines of immune defense against bacteria, viruses, and fungi.
People dealing with chronic or recurrent infections report notable improvement. Stubborn infections that seem to resist treatment become more manageable. Wound healing accelerates. Overall immune resilience strengthens. It's particularly valued by people dealing with biofilm-related infections — the kind where bacteria form protective colonies that antibiotics struggle to penetrate.
Beyond direct antimicrobial action, LL-37 also coordinates the immune response — calling in reinforcements, promoting blood vessel formation at wound sites, and modulating inflammation. It's not just killing pathogens; it's organizing the body's entire defense and repair response.
How LL-37 works
LL-37 works in two complementary ways. First, it directly disrupts the membranes of bacteria, viruses, and fungi — essentially punching holes in their protective walls. Second, it acts as an immune coordinator by modulating TLR signaling (the alarm system that detects invaders), attracting immune cells to the site of infection (chemotaxis), and stimulating the growth of new blood vessels to support healing. It also breaks down biofilms — the protective shields that some bacteria build to resist antibiotics.
Scientific overview
LL-37 is the only human cathelicidin antimicrobial peptide. It plays a crucial role in innate immune defense against bacteria, viruses, and fungi. Beyond its direct antimicrobial activity, LL-37 modulates immune responses, promotes wound healing, stimulates angiogenesis, and has anti-biofilm properties.
Dosing
- Starting dose: 50 mcg per day
- Common dosage range: 50-100 mcg per day
- Administration: Subcutaneous
- Half-life: ~4 hours
- Frequency: 1x daily