CagriSema Stack
The dual-pathway weight management powerhouse — two proven compounds targeting both GLP-1 and amylin receptors in a single weekly injection
CagriSema represents the most validated combination approach to weight management available today. By combining cagrilintide and semaglutide in a single weekly injection, it targets two completely different hunger and metabolism pathways simultaneously.
Semaglutide is a GLP-1 receptor agonist that fundamentally changes your relationship with food. It reduces appetite signals in the brain, slows gastric emptying so you feel fuller longer, and improves insulin sensitivity. It's the same compound behind some of the most dramatic weight loss results in clinical history. Cagrilintide is a long-acting amylin analog that works through a separate receptor system entirely. Amylin is naturally released alongside insulin after meals — it signals satiety, slows stomach emptying through a different mechanism than GLP-1, and reduces glucagon secretion.
The reason this combination outperforms either compound alone is simple: two different receptor systems controlling appetite and metabolism are better than one. Phase 3 trials showed up to 25% body weight reduction — significantly more than semaglutide alone. Many people who plateaued on GLP-1 therapy alone find that adding the amylin pathway breaks through the ceiling.
Component peptides
- Cagrilintide — Amylin receptor agonist for satiety and gastric slowing: Titrated up to 2.4 mg/week SubQ
- Semaglutide — GLP-1 receptor agonist for appetite suppression and metabolic regulation: Titrated up to 2.4 mg/week SubQ
Combined dosing protocol
CagriSema is typically pre-mixed in a single vial and administered as one subcutaneous injection once per week, on the same day each week. The target maintenance dose is approximately **4.8 mg of the combined stack** per week (~2.4 mg cagrilintide + ~2.4 mg semaglutide). Dosing is titrated up gradually — starting low and increasing every 4 weeks as tolerated to minimize GI side effects. Plug the total stack mg into our dosing calculator along with your vial size and reconstitution volume to get the exact number of syringe units to draw. Inject in the abdomen, thigh, or upper arm, rotating injection sites. No fasting is required, though many people prefer to inject in the morning.
Notes
Most people notice a significant reduction in appetite and food noise within the first 1-2 weeks. Nausea is the most common side effect during dose escalation — eating smaller, more frequent meals and staying hydrated helps. Weight loss results are typically steady and progressive, with the most dramatic changes visible over 3-6 months. Protein intake is important to preserve muscle mass during weight loss.