AOD-9604
Modified growth hormone fragment specifically targeting fat metabolism
Clinical Research Score: 4/5 — Reached human obesity clinical trials and holds GRAS status for some uses, though trials didn't establish enough efficacy for drug approval.
Categories: Weight Loss / Metabolic
What is AOD-9604?
AOD-9604 takes the fat-burning power of growth hormone and isolates it — giving you the body composition benefits without the blood sugar issues, water retention, or growth effects that make full HGH problematic.
People report that stubborn fat deposits — the kind that seem immune to diet and exercise — finally start responding. Love handles, lower belly fat, that persistent layer that won't budge. AOD-9604 targets fat metabolism specifically, telling the body to break down stored fat while simultaneously preventing it from storing new fat.
What makes it appealing is the simplicity and the safety profile. It's a fragment of the growth hormone molecule, engineered to retain only the metabolic effects. No joint swelling, no insulin resistance, no numbness in the hands. It's a focused, targeted tool for fat loss — nothing more, nothing less.
How AOD-9604 works
AOD-9604 is a fragment of the growth hormone molecule (amino acids 177-191) that retains only the fat-metabolizing action. It activates the beta-3 adrenergic receptor, which triggers the breakdown of stored fat (lipolysis) while simultaneously blocking the formation of new fat (lipogenesis). Crucially, it does this without affecting blood sugar levels or stimulating growth — it's purely a metabolic signal that tells your body to burn fat for fuel.
Scientific overview
AOD-9604 is a modified fragment of human growth hormone (hGH) comprising amino acids 177-191, with an added tyrosine at the N-terminal end. It was specifically designed to have the fat-reducing effects of growth hormone without the diabetogenic or growth-promoting effects. It stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) in both animal and human studies.
Dosing
- Starting dose: 300 mcg per day
- Common dosage range: 300-600 mcg per day
- Administration: Subcutaneous
- Half-life: ~12 hours
- Frequency: 1x daily (morning, fasted)