5-Amino-1MQ
NNMT inhibitor that boosts cellular energy and promotes fat loss
Clinical Research Score: 2/5 — Backed by preclinical (animal and lab) research on NNMT inhibition for fat loss, with no human trials and growing anecdotal use.
Categories: Weight Loss / Metabolic, Performance & Energy
What is 5-Amino-1MQ?
5-Amino-1MQ takes a backdoor approach to fat loss that most people haven't heard of — and it's remarkably elegant. Instead of directly burning fat or suppressing appetite, it inhibits an enzyme (NNMT) that your fat cells use to slow down their own metabolism. Block that enzyme, and fat cells start burning energy at a higher rate.
People report a gradual but steady improvement in body composition — fat slowly reduces while energy levels increase. It's not dramatic overnight, but the trajectory is consistent. Metabolism feels "faster" — people describe generating more body heat, having more energy, and finding that their weight management efforts are suddenly more productive.
The bonus is that by inhibiting NNMT, 5-Amino-1MQ also increases NAD+ levels — the same molecule that dedicated NAD+ supplements target. So you're getting metabolic enhancement and anti-aging cellular support in one compound. It's convenient and increasingly popular in body recomposition protocols.
**Typical injection dosing:** A common experimental subcutaneous dose is 5-10 mg once daily, taken in the morning to align with your natural circadian metabolic rhythm. Because oral bioavailability is only around 20-30%, a 5-10 mg subQ dose is roughly equivalent to a 50 mg oral capsule — you need far less when injecting. Most protocols run 6-8 weeks maximum, followed by a 4-week break to let your body re-baseline its NAD+ levels and metabolic response before starting another cycle.
How 5-Amino-1MQ works
5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that consumes NAD+ and promotes fat storage in adipocytes. By blocking NNMT, the compound achieves two things simultaneously: it increases cellular NAD+ availability (which activates SIRT1 longevity pathways and boosts cellular energy production) and it reduces lipogenesis (fat formation) in fat cells while increasing energy expenditure. It essentially removes a metabolic roadblock that makes fat cells stubbornly hold onto stored energy.
Scientific overview
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism. By inhibiting NNMT, 5-Amino-1MQ increases NAD+ levels, activates SIRT1, and shifts cellular metabolism toward increased energy expenditure. It has shown potential for treating obesity and metabolic dysfunction.
Dosing
- Starting dose: 5 mg subQ per day
- Common dosage range: 5-10 mg subQ per day
- Administration: Subcutaneous
- Half-life: ~8 hours
- Frequency: 1x daily (morning)