CJC-1295 (no DAC)
Growth hormone releasing hormone analog that provides sustained GH elevation
Clinical Research Score: 4/5 — Human pharmacology studies confirm it raises growth hormone and IGF-1, but it has not advanced through full clinical approval.
Categories: Hormonal Support, Performance & Energy, Anti-Aging / Longevity
What is CJC-1295 (no DAC)?
CJC-1295 is the amplifier in the growth hormone equation. While peptides like Ipamorelin trigger a single pulse of GH, CJC-1295 extends and sustains that pulse, keeping growth hormone levels elevated for much longer. It's the difference between a brief flash and a sustained glow.
People report steady, progressive improvements in body composition — fat slowly melts away while lean tissue firms up. Sleep quality improves noticeably. Recovery between workouts shortens. Skin starts looking healthier and more elastic. These changes aren't dramatic overnight, but they're consistent and cumulative.
CJC-1295 is rarely used alone — it's almost always paired with Ipamorelin. Together, they form one of the most popular and well-researched GH optimization combinations in the peptide world. The pairing produces GH levels 3-5 times greater than either alone, making it the gold standard for anyone serious about natural growth hormone optimization.
How CJC-1295 (no DAC) works
CJC-1295 works by stimulating the GHRH receptors on the pituitary gland — the same receptors that your body's own growth hormone releasing hormone uses. But CJC-1295 has been modified to resist the enzymes that normally break down GHRH in minutes. The result is a sustained signal that keeps GH elevated in a natural, pulsatile pattern without desensitizing the pituitary. It essentially extends the body's own GH production window.
Scientific overview
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that has been modified to resist enzymatic degradation, resulting in a much longer half-life than natural GHRH. When combined with Drug Affinity Complex (DAC), it can extend the half-life even further. It stimulates growth hormone secretion in a pulsatile manner that mimics natural GH release patterns.
Dosing
- Starting dose: 100 mcg per dose (no DAC)
- Common dosage range: 100-300 mcg per dose (no DAC) or 2mg per week (with DAC)
- Administration: Subcutaneous
- Half-life: ~30 minutes (no DAC) or ~8 days (with DAC)
- Frequency: 1-3x daily (no DAC) or 1-2x per week (with DAC)