TB-500
Thymosin Beta-4 fragment that promotes healing, reduces inflammation, and supports tissue repair
Clinical Research Score: 4/5 — Its parent molecule, Thymosin Beta-4, has been studied in human clinical trials for tissue repair, though the TB-500 fragment itself remains investigational.
Categories: Recovery & Repair, Immune Support
What is TB-500?
TB-500 is the other half of the legendary healing duo (alongside BPC-157), and it brings something unique to the table. Where BPC-157 builds the infrastructure for healing, TB-500 is the workforce — it physically moves repair cells to the injury site.
People report remarkable results with muscle strains, tendon injuries, and chronic inflammation. Flexibility improves. Stiffness fades. Injuries that have lingered for months suddenly start progressing. Athletes and active individuals describe it as the difference between their body slowly patching things up and aggressively rebuilding.
The long-lasting effects are another standout feature. Because TB-500 stays active in the body for days (not hours), the healing signal is continuous. Many people use it alongside BPC-157 for what the community calls the "Wolverine Stack" — a combination that addresses healing from two complementary angles.
How TB-500 works
TB-500 works by interacting with actin, one of the most important structural proteins in your cells. This interaction dramatically increases cell migration — meaning repair cells can physically travel to damaged areas much faster. It also reduces inflammation body-wide, promotes the formation of new blood vessels to feed healing tissue, and upregulates the proteins your body needs to rebuild. Think of it as dispatching and accelerating your body's repair crews.
Scientific overview
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tb4). It plays a fundamental role in protection, regeneration, and remodeling of injured or damaged tissues. The peptide promotes cell migration, blood cell and blood vessel development, and has potent anti-inflammatory properties. It is involved in actin regulation, which is critical for cell structure and movement.
Dosing
- Starting dose: 2 mg per week
- Common dosage range: 2-5 mg per week
- Administration: Subcutaneous, Intramuscular
- Half-life: ~14 days (active)
- Frequency: 2x per week during loading, 1x per week maintenance