CJC-1295 + Ipamorelin Stack
The classic growth hormone duo — the most popular and well-established peptide combination for naturally boosting GH levels
CJC-1295 + Ipamorelin is the most widely used growth hormone secretagogue combination in the peptide world, and for good reason. These two peptides target different receptor pathways to create synergistic GH pulses that are significantly more powerful than either compound alone.
CJC-1295 (Modified GRF 1-29, without DAC) is a GHRH analog — it tells your pituitary gland to release growth hormone through the GHRH receptor. Think of it as turning up the volume on your body's natural GH signal. Ipamorelin is a selective ghrelin mimetic that triggers GH release through a completely different receptor (GHSR). It's considered the cleanest GH-releasing peptide available because it doesn't significantly affect cortisol, prolactin, or appetite — just growth hormone.
When you combine them, CJC-1295 amplifies the baseline GH signal while Ipamorelin triggers acute GH pulses on top of that elevated baseline. The result is GH levels 3-5x greater than either peptide alone. Users consistently report improved sleep quality (often from night one), better body composition over time, faster workout recovery, improved skin quality, and increased energy. This combination is widely considered the foundation of most peptide protocols — many people start here and add other peptides on top of it.
Component peptides
- CJC-1295 (no DAC) — GHRH analog for sustained growth hormone signaling: 100-300 mcg/dose SubQ
- Ipamorelin — Selective ghrelin mimetic for clean GH pulses: 200-300 mcg/dose SubQ
Combined dosing protocol
CJC-1295 + Ipamorelin is typically pre-mixed in a single vial and administered as one subcutaneous injection. A standard dose is approximately **300-600 mcg of the combined stack** per injection (delivering ~100-300 mcg CJC-1295 + ~200-300 mcg Ipamorelin). Plug the total stack mcg into our dosing calculator along with your vial size and reconstitution volume to get the exact number of syringe units to draw. The most effective timing is before bed on an empty stomach — at least 2 hours after your last meal — to amplify the natural GH surge during deep sleep. Many people add a second dose first thing in the morning, also on an empty stomach. Avoid eating (especially carbs) for 30 minutes after injection, as insulin blunts GH release. Standard cycles run 8-12 weeks with a 4-week break.
Notes
This is the most popular entry point into peptide therapy for a reason — it's effective, well-tolerated, and the benefits are noticeable quickly. Most people report improved sleep within the first few days. Body composition, recovery, and skin improvements build over 4-8 weeks. Often used as a foundation stack that other peptides are layered on top of.